The association between Interleukin-37 and Allergic rhinitis and its severity

Document Type : Review Articles

Authors

1 ENT , Faculty of medicine ,fayoum university

2 Department of Otorhinolaryngology-Faculty of Medicine - Fayoum University.

3 Medical Biochemistry and Molecular Biology - Fayoum university- Fayoum

Abstract

Over the last 20 years, the pathogenesis of AR has been widely investigated and the majority of studies have focused on pro inflammatory cytokines. However, anti-inflammatory cytokines in AR have received less attention. Interleukin (IL)-37, a novel member of the IL-1 family and originally termed IL-1F7, has been shown to be a natural suppressor of innate immunity and inflammatory responses. Various normal immune and non-immune cells and tissues express IL-37 including, stimulated B cells, natural killer cells, monocytes, epithelial cells, skin keratinocytes, thymus, lymph nodes, lung and bone marrow .Regarding this point, IL-37 has been considered a key player in a variety of inflammatory and autoimmune diseases ( for instance, inflammatory respiratory diseases, inflammatory bowel diseases, rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, psoriasis and multiple sclerosis ) , and studies have shown dysregulated expression of IL-37 under these conditions.
The Aim of This Study is to assess the association between interleukin 37 and allergic rhinitis and its severity.
This study investigated the relationship between IL-37 levels and various health factors among participants. The results demonstrated significant differences in IL-37 levels between cases and controls, both in blood and after nasal lavage, suggesting potential role of IL-37 as anti-inflammatory cytokine in development of allergic rhinitis disease and its severity

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Fayoum University Medical Journal
Volume 15, Issue 3
Surgical sub-specialties
September 2025
Pages 1-10

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