The Possible Association between Thyroid Dysfunction in Male Rat Model and Serum Irisin Level and Glycemic Status ///

Dahman, Eman A.; Abdelwahed, Mostafa Yehia; Khamiss, Mohammed Mahmoud; Mahmoud, Rania Hosny; Mizar, Sayed. M.; Ali, Amani M. El Amin

doi:10.21608/fumj.2025.332071.1416

The Possible Association between Thyroid Dysfunction in Male Rat Model and Serum Irisin Level and Glycemic Status ///

Document Type : Full Length research Papers

Authors

¹ Medical Physiology department, faculty of Medicine, Fayoum University,

² Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum

³ Pharmacology and Toxicology department, Faculty of pharmacy Fayoum university

10.21608/fumj.2025.332071.1416

Abstract

Abstract
Introduction: Insulin resistance, energy balance, and pancreatic beta cell function are some of the processes via which thyroid dysfunctions are strongly linked to glucose intolerance.
The purpose the research: We aimed to assess the correlation between serum irisin and thyroid dysfunction (hypo- and hyperthyroidism), as well as the relationship between these parameters and glycemic status.
Methodology: 45 mature male albino strain rats weighing between 200 and 250 grams were used in this experimental investigation. Three equal groups were formed: The hypothyroid cohort was administered 50 mg of propylthiouracil (PTU) per kilogram of body weight per day for four weeks. the hyperthyroid group got increasing doses of levothyroxine sodium (starting at 50 μg and reaching up to 200 μg/Kg body weight daily), and the control group stayed without medication.
Results: The hypothyroid group demonstrated a notable reduction in serum fT3, fT4, HOMA B, and BMI, alongside a noteworthy increase in serum TSH, irisin, fasting insulin, fasting glucose, and HOMA IR when compared to the control group. Nevertheless, HOMA B, TSH, BMI, and irisin levels were significantly lower in the hyperthyroid group, accompanied by a significant rise in serum fT3, fT4, fasting insulin, fasting glucose and HOMA IR. Furthermore, serum irisin correlated positively with TSH levels but negatively with fT3 and fT4 levels.
Conclusion: Our study supports the hypothesised relationship between irisin and thyroid hormones (THs) and shows that THs may be in vivo regulators of irisin secretion.

Keywords