Osteocalcin Level in Children with Nephrotic Syndrome: A Systematic Review

Document Type : Review Articles

Authors

1 Department of Pediatrics , Fayoum General Hospital,Fayoum, Egypt

2 Pediatric Department, Faculty of Medicine, Fayoum University,Fayoum, Egypt

3 Pediatric department , Faculty of medicine , Fayoum university , Fayoum , Egypt

4 Department of clinical pathology, Faculty of Medicine, Fayoum University, Fayoum, Egypt

Abstract

Background
Osteocalcin (OC) is a protein hormone that is improtant in bone metabolism. OC levels have been impacted in children exhibit nephrotic syndrome (NS), which is defined by inflammation and protein loss in urine.
Methods
I conducted a systematic examination to assess the serum osteocalcin (S-OC) level in children with NS. This subset data consisted of 975 children.
Results
A review of 10 studies, which included 975 children, determined remission as the lack of albumin in three consecutive early morning urine samples (or proteinuria <4 mg/m2/h). A tolerance on steroids was detected by two consecutive relapses throughout alternate day steroid utilization or within 2 weeks of quitting steroids. Steroid Resistant NS is defined as the inability to achieve recovery after four weeks of medication with 2 mg/kg/day of prednisolone.
Conclusion
The increase in OC levels depends on the dosage of glucocorticoids given, not on the particular kind of GC prescribed. This could have importance in clinical and could help reduce bone-related side effects. When vitamin D supplementation is provided, the utilization of multiple courses of steroid therapy usually has no impact on height as a growth parameter. It is not recommended to utilize OC as a screening tool in children on steroids, as the rise in serum levels may occur due to either bone turnover or formation.

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