Document Type : Full Length research Papers
Authors
1
Dermatology & Venerology department, faculty of medicine,fayoum university,Fayoum,Egypt
2
Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum
3
Dermatology and venereology department, faculty of medicine,fayoum university,Fayoum, Egypt
4
Dermatology and venereology department ,faculty of medicine,Fayoum University,Fayoum,Egypt
Abstract
Introduction: The relationship between High-Density Lipoprotein (HDL) and leprosy is a relatively underexplored area of research, but emerging studies suggest that HDL may play a role in the management of the disease.
Aim of the study: To assess the relation between the levels of High-density lipoprotein (HDL) and leprosy.
Subjects and Methods: We searched Cochrane, Web of Science, PubMed, and SCOPUS for relevant articles. We utilized a strategy for our search by combining these keywords: ( ‘’ High-density lipoprotein ’’ OR ‘’ HDL ’’ ) AND (‘’ Leprosy ‘’ OR ‘’ Mycobacterium leprae ‘’ OR ‘’ Lepromatous leprosy ‘’ OR ‘’ Tuberculoid leprosy ‘’). Quality evaluation of the involved studies was assessed regarding to Cochrane’s risk of bias tool (ROB).
Results: Our meta-analysis included four articles. We found that leprosy patients had lower levels of HDL. Additionally, the HDL and TC levels was similar in both cohorts (paucibacillary and Multibacillary) without any substantial variations (MD = 8.57 [-12.70, 29.85], P = 0.43) and (MD = -7.43 [-24.07, 9.22], P = 0.38), respectively.
Conclusions: Leprosy accompanied by decreased levels of HDL in the patients and the treatment of leprosy may help in the elevation of HDL levels slightly. That’s why HDL plays a crucial role in the follow-up of leprosy progression and assessing the effectiveness of MDT for the management of leprosy.
Keywords: High-density lipoprotein, Mycobacterium leprae, Leprosy, Lepromatous leprosy, Tuberculoid leprosy.
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