Interleukins gene polymorphism in alopecia areata patients: a systematic review

Document Type : Review Articles

Authors

1 Dermatology and Venerology department ,Faculty of medicine, Fayoum university.

2 dermatology department fayoun university

3 Biochemistry and Molecular Biology faculty of medicine, Fayoum University

4 Dermatology, Faculty of medicine, Minia University

Abstract

Background: Alopecia areata (AA) is an autoimmune disorder that causes hair loss without scarring on the scalp or any part of the body with hair.There are various genetic variations in the interleukin genes, although the findings are inconsistent. This systematic study aimed to determine the correlation among specific genes (12B, 15, 16, 13, 12, 17A, 23, 17RA, and 18) of the interleukin family and alopecia areata.
Aim and objective: The objective of this investigation is to assess the potential connection between gene variation in interleukins and a Probability of getting alopecia areata, as well as to examine its correlation with illness severity.
Patients and methods: This systematic review included all relevant case-control association trials that included cases with alopecia areata & healthy controls.
Conclusion: Alopecia areata is associated with IL-17A, IL-18, IL17RA, and IL16 gene polymorphisms. More genetic studies should be conducted to ensure that interleukins play a role in the progression of alopecia areata.

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Fayoum University Medical Journal
Volume 15, Issue 1
Medical Sub specialty
April 2025
Pages 34-44

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