Association Between VIT D Level and VIT D Receptors Expression with The Risk of Keloid and Hypertrophic Scar Formation: A Systematic Review and Meta-Analysis

Ishak, Mary Mageed; Hassan, Amel Raouf; El- Tahlawi, Samar Mohamed; Elamir, Azza Mohamed

doi:10.21608/fumj.2025.315556.1385

Association Between VIT D Level and VIT D Receptors Expression with The Risk of Keloid and Hypertrophic Scar Formation: A Systematic Review and Meta-Analysis

Document Type : Review Articles

Authors

¹ Dermatology and venerology depatment, Faculty of medicine, Fayoum university, Fayoum, Egypt

² Dermatology Faculty of Medicine, Cairo University

³ medical biochemistry and molecular biology department, faculty of medicine, fayoum university

10.21608/fumj.2025.315556.1385

Abstract

Abstract
Introduction: Keloids and hypertrophic scars are benign fibroproliferative growths that develop on the skin following aberrant wound healing. They can happen on their own or are often brought on by skin traumas such as burns, trauma, skin inflammation, and surgery.
Aim of the study: To collect the data about the levels of vitamin D and vitamin D receptor expression and scar formation.
Subjects and Methods: We searched through Cochrane, Web of Science, PubMed , and SCOPUS to find eligible articles. Quality evaluation of the studies was carried out using Cochrane’s risk of bias tool. The outcomes included in our analysis were: vitamin D receptor (VDR) expression, serum 25-hydroxy vitamin D (25(OH)D) level, insufficient, normal, and deficient serum 25(OH)D levels.
Results: Seven articles were included in our research. The study revealed that Serum 25(OH)D levels were significantly reduced in keloid patients compared to the control group. Additionally, the keloid cohort showed lower levels of VDR expression, and higher levels of insufficient and deficient serum 25(OH)D than the control cohort which was not statistically significant.
Conclusions: In conclusion, we discovered that the deficiency of vitamin D was more frequent in hypertrophic scar and keloid patients compared to healthy individuals. Additionally, Keloid patients were associated with vitamin D expression deficiency and higher levels of insufficient, and deficient serum 25(OH)D than the healthy patients.

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