SLE is a multi-system autoimmune disease, with complex etio-pathogenesis, variable clinical presentations, severity, and treatment responses. Aim of the work: To assess the serum level of macrophage colony stimulating factor (M-CSF) among SLE patients, and its relation to disease activity, renal involvement, peripheral vascular affection, and other disease characteristics. Patients and methods: The current study included 50 SLE patients and 50 healthy controls. The patients included were diagnosed according to the 2019 EULAR/ACR criteria for SLE diagnosis. patients were subjected to full history taking, clinical examination, laboratory investigations, nailfold capillaroscopy assessment, and renal biopsy. Disease activity was assessed by (SLEDAI-SELENA) modification. M-CSF levels were measured (in patients and controls) using ELISA technique. Results: The mean age of SLE patients was 33.9±10.8 years; they were 47 females and 3 males; disease duration was 5.9±5.4 years; and 12% of SLE patients had a positive family history. Cutaneous and musculo-skeletal manifestations were among the most common clinical manifestations. Class IV was the most common histopathological finding. Abnormal nailfold capillaroscopy findings were found in 92% of SLE patients; minor changes were more common than major ones. M.CSF levels were elevated among SLE patients than healthy controls with a p-value <0.05, and their levels significantly related to different renal biopsy classes, with higher levels in patients with class V, IV, and III, respectively. Conclusion: M.CSF level was elevated among SLE patients compared with healthy controls with a p-value <0.05, and was significantly related to different renal biopsy classes.
Fouad, N., & Abdelaleem, O. (2024). Detection of Macrophage Colony Stimulating Factor in Systemic Lupus Erythematosus Patients and its Relation to Disease Activity and Severity. Fayoum University Medical Journal, 13(3), 57-71. doi: 10.21608/fumj.2024.266346.1312
MLA
Nermeen Ahmed Fouad; Omayma Owees Abdelaleem. "Detection of Macrophage Colony Stimulating Factor in Systemic Lupus Erythematosus Patients and its Relation to Disease Activity and Severity", Fayoum University Medical Journal, 13, 3, 2024, 57-71. doi: 10.21608/fumj.2024.266346.1312
HARVARD
Fouad, N., Abdelaleem, O. (2024). 'Detection of Macrophage Colony Stimulating Factor in Systemic Lupus Erythematosus Patients and its Relation to Disease Activity and Severity', Fayoum University Medical Journal, 13(3), pp. 57-71. doi: 10.21608/fumj.2024.266346.1312
VANCOUVER
Fouad, N., Abdelaleem, O. Detection of Macrophage Colony Stimulating Factor in Systemic Lupus Erythematosus Patients and its Relation to Disease Activity and Severity. Fayoum University Medical Journal, 2024; 13(3): 57-71. doi: 10.21608/fumj.2024.266346.1312
)
View on SCiNiTO