Long non-coding RNA RMRP in autoimmune diseases: A systematic review

Document Type : Review Articles

Authors

1 Dermatology Department, Faculty of Medicine , Fayoum University

2 Dermatology, Faculty of medicine, Minia University

3 Fayoum

4 medical biochemistry and molecular biology department, faculty of medicine, fayoum university

Abstract

Background

Long non-coding RNAs (lncRNAs) are a recently identified group of non-coding RNAs that do not include instructions for protein synthesis. These RNAs possess many crucial regulatory roles. The aberrant expression of lncRNAs has been related with the clinical progression of several illnesses, making them potential candidates for diagnostic biomarkers.

Objectives

To evaluate lncRNAs RMRP may be consider as diagnostic marker in autoimmune diseases.

Patients and methods

Original studies were included in our search results from PubMed, Medline, & EMBASE. Review papers were not included. Research has to have published one or more lncRNA that were found by their experiments.



Results

The study found elevated expression levels of RMRP & FLICR in MS cases, with FLICR being effective in distinguishing between patients and healthy controls. However, RMRP expression in peripheral blood showed insignificant increases, suggesting RMRP may play a crucial role in chondrocyte hypertrophy.

Conclusion

Regarding these findings, lncRNAs RMRP may be consider as diagnostic marker in autoimmune diseases.

Keywords
Long non-coding RNA, RMRP, marker, autoimmune diseases.

Keywords

Main Subjects

Fayoum University Medical Journal
Volume 13, Issue 3
Medical Subspecialty
April 2024
Pages 1-10

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