Document Type : Full Length research Papers
Authors
1
Dermatology, STDs and Andrology Department, Faculty of Medicine, Cairo University
2
Dermatology Department, Faculty of Medicine, Fayoum University
3
Dermatology Faculty of medicine fayoum university fayoum egypt
Abstract
Introduction: Acne, which is an inflammatory disease of the pilosebaceous unit, can be
triggered by a wide variety of different factors. Acne that develops for the first time in women over the age of 25 is referred to as adult-onset female acne. There are three different types: recurrent, late-onset, and
persistent.
Aim of the study: Individuals with late-onset adult female acne and an age-matched control group were compared with regard to their total testosterone, DHEAs, SHBG, C peptide, TSH, FSH, LH, and lipid profile. Also taken into consideration was the presence or absence of lipid abnormalities.
Subjects and Methods: The current case-control study was carried out on a total of one hundred adult females, fifty of whom were affected by acne, while the remaining fifty served as controls. Fasting lipid profiles and androgen levels (including total testosterone, sex hormone-binding globulin, dehydroepiandrosterone sulphate, luteinizing hormone, follicular stimulating hormone, thyroid stimulating hormone, and C-peptide) were measured in patients as well as healthy controls. ELISA (enzyme-linked immunosorbent assay) kits were used for each and every one of the hormone measurements that were taken.
Results: C-peptide, DHEAs, and TSH levels all varied significantly from one another, mathematically speaking (P < 0.01). The levels of LH and testosterone were found to differ from one another in a way that was statistically significant (P > 0.05). In addition, there was not a statistically significant difference between the two groups in terms of FSH or SHBG levels (P > 0.05). It was determined that there was no statistically significant difference (P > 0.05) in the levels of cholesterol, triglycerides, HDL, or LDL between the participant group and the control group.
Conclusion: The findings lead researchers to believe that serum levels of C peptide, DHEAs, TSH, total testosterone, and LH might play a part in the pathogenesis of late-onset adult female acne vulgaris. On the other hand, it was discovered that FSH, SHBG, and lipid profile did not play any part in the development of the disease.
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