Role of Epidermal Growth Factor in Oral Lichen Planus

Authors

1 professor of Dermatology, STDs and andrology department, Faculty of Medicine Fayoum University.

2 professor of biochemistry , Faculty of Medicine Cairo university.

3 lecturer of Dermatology, andrology and STDs, Faculty of Medicine Fayoum University.

4 Department of Dermatology, Faculty of Medicine Fayoum University.

Abstract

OLP is the mucosal counterpart of cutaneous LP which is a chronic mucocutaneous disorder of stratified squamous epithelium that affects oral and genital mucous membranes, skin, nails, and scalp. Epidermal Growth Factor (EGF) is the prototypical member of a family of peptide growth factors that activate the EGFR, Despite the strong association of EGFR over expression with oral carcinogenesis, although few studies have analyzed its expression in OLP. The aim of this work is to measure serum and tissue levels of EGF in patients with oral lichen planus in comparison to normal controls, in order to investigate the role of EGF in the pathogenesis of oral lichen planus. This study was conducted in Dermatology, STDs and Andrology Department of Fayoum University Hospital in the period between March 2017 and February 2018. 49 patients were included, 29 patients had OLP and 20 apparently healthy volunteers as control group. Our results shows statistically significant correlation between EGF and OLP (p value ≤ 0.001) denoting the strong correlation between EGF and OLP.
 

Keywords

Fayoum University Medical Journal
Volume 1, Issue 2
December 2018
Pages 5-8

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