@article { author = {Mostafa, Randa and Elsamanoudy, Aymen}, title = {Is It Time To Flip}, journal = {Fayoum University Medical Journal}, volume = {1}, number = {2}, pages = {1-4}, year = {2018}, publisher = {Fayoum University, Faculty of Medicine}, issn = {2536-9474}, eissn = {2536-9482}, doi = {10.21608/fumj.2018.31287}, abstract = {}, keywords = {}, url = {https://fumj.journals.ekb.eg/article_31287.html}, eprint = {https://fumj.journals.ekb.eg/article_31287_0b5890b7404b1d60024577b457bd5e5b.pdf} } @article { author = {Abd-ElRaheem, Talal and Shaker, Olft and Mohamed, Mohamed and Ahmed, Aya}, title = {Role of Epidermal Growth Factor in Oral Lichen Planus}, journal = {Fayoum University Medical Journal}, volume = {1}, number = {2}, pages = {5-8}, year = {2018}, publisher = {Fayoum University, Faculty of Medicine}, issn = {2536-9474}, eissn = {2536-9482}, doi = {10.21608/fumj.2018.31289}, abstract = {OLP is the mucosal counterpart of cutaneous LP which is a chronic mucocutaneous disorder of stratified squamous epithelium that affects oral and genital mucous membranes, skin, nails, and scalp. Epidermal Growth Factor (EGF) is the prototypical member of a family of peptide growth factors that activate the EGFR, Despite the strong association of EGFR over expression with oral carcinogenesis, although few studies have analyzed its expression in OLP. The aim of this work is to measure serum and tissue levels of EGF in patients with oral lichen planus in comparison to normal controls, in order to investigate the role of EGF in the pathogenesis of oral lichen planus. This study was conducted in Dermatology, STDs and Andrology Department of Fayoum University Hospital in the period between March 2017 and February 2018. 49 patients were included, 29 patients had OLP and 20 apparently healthy volunteers as control group. Our results shows statistically significant correlation between EGF and OLP (p value ≤ 0.001) denoting the strong correlation between EGF and OLP.  }, keywords = {Oral lichen planus,epidermal growth factor,lichen planus}, url = {https://fumj.journals.ekb.eg/article_31289.html}, eprint = {https://fumj.journals.ekb.eg/article_31289_4e0ec5483ac010e5916c0b4b8d8104b2.pdf} } @article { author = {Abdelgaffar, Sara and Salem, Mohammed and Elkayal, Engy and Youssef, Ashraf and Ragheb, Ahmed}, title = {Role of Strain Elastography in Assessment of Cervical Incompetence}, journal = {Fayoum University Medical Journal}, volume = {1}, number = {2}, pages = {9-18}, year = {2018}, publisher = {Fayoum University, Faculty of Medicine}, issn = {2536-9474}, eissn = {2536-9482}, doi = {10.21608/fumj.2018.31292}, abstract = {Background: Obstetricians exert a lot of efforts to decrease the rate of perinatal morbidity and mortality of mothers and their offspring. Preterm delivery is known to be one of the chief causes for this burden. The aim of this study was to estimate the potential value of elastographic evaluation of cervical canal stiffness at 12-14 weeks of pregnancy in women with cervical incompetence in the prediction of spontaneous preterm delivery. Patient and Methods: This prospectiveobservational study included 40 women presenting for the routine first trimester ultrasound scan between 12-14 weeks of pregnancy. Ultrasound examinations of the cervix were performed transvaginally (TV). The following data were recorded: elastographic color assessment of the cervical canal and ultrasound cervical length at 12-14 and weeks of pregnancy; maternal age; obstetrical history; gestational age at birth. Elastographic assessment of the cervical canal wasperformed using a color map: Red (soft), Yellow (medium soft), Green (medium hard) and Purple (hard). If two colors were visible in the region of the cervical canal, the softer option was noted. The collected data were organized, tabulatedand statistically analyzed using SPSS software statistical computer package version 18 (SPSS Inc., USA). For quantitative data, the mean, standard deviation (SD), and range were calculated. Mann-Whitney-U test and Kruskal- Wallis test were used as a test of significance to compare between two and three groups, respectively. Qualitative data were presented as number and percentages, chi square (χ2) was used as a test of significance. Spearman correlation test was run to identify relation between cervical elasticity and cervical length. For interpretation of results of tests of significance, significance was adopted at p value ≤ 0.05. Results: The number of preterm deliveries ( <37 weeks of pregnancy) was significantlyhigher in the Red and Yellow groups, than inthe Green and Purple groups. The sensitivity, specificity, NPV and PPV in predicting preterm delivery for Red color group in patients withcervix length ˂ 25 mm were 62.5%, 71.9%, 35.7% and 88.5% respectively with total accuracy of 70% . When adding the “yellow color” the sensitivity was raised to 87.5%, yet, the specificity dropped to 62.5% and the total accuracy dropped to 67.5%. Conclusion: Elastographic assessment of thecervical canal at 12-14 weeks of pregnancy may identify patients with high risk of preterm delivery in women with cervical incompetence.  }, keywords = {Elastography,Preterm Delivery,Ultrasonography,Cervical canal assessment}, url = {https://fumj.journals.ekb.eg/article_31292.html}, eprint = {https://fumj.journals.ekb.eg/article_31292_463033c73d794b7d3f5c4be1e1e07241.pdf} } @article { author = {Elkhashab, Khaled and Elshafie, Shahira and Abd El Razek, Gomaa and EL Sakhewy, Ahmed}, title = {Relation between Red Blood Cell Distribution Width and Left Ventricular Function In Acute Coronary Syndrome Patients}, journal = {Fayoum University Medical Journal}, volume = {1}, number = {2}, pages = {19-35}, year = {2018}, publisher = {Fayoum University, Faculty of Medicine}, issn = {2536-9474}, eissn = {2536-9482}, doi = {10.21608/fumj.2018.31293}, abstract = {Red blood cells distribution width (RDW) is a measure of red blood cell width variation, reported as part of a standard complete blood count; although it is usually measured, as a routine test, actually its values have been only used in the differential diagnosis of anemia and high values indicate the presence of anisocytosis. It has been demonstrated thatRDW could be considered an independent prognostic marker of cardiovascular events in patients with heart failure and peripheral artery diseases. However the role of RDW in patients with acute coronary syndromes (ACS) is less known.Methods: This study included 40 consecutive patients presented with chest pain suggestive of the acute coronary syndrome. Participating subjects were subjected to a detailed history, complete physical examination 12- lead ECG,and routine laboratory investigations including serum cardiac markers and complete blood count including RDW were performed and echocardiography examination including ejection fraction and tissue Doppler. Results: The study showed statistically significant positive correlation with p-value<0.05 between RDW and each of Left atrium, End systolic, and End diastolic dimensions in echo finding which indicates increase in RDW had positive impact on increase of Left atrium,End systolic, and End diastolic, Resting wall motion abnormalities On the other hand there is negative statistically significance correlation with p-value <0.001 between RDW and Ejection fraction which indicates increase in RDW had negative impact on Ejection fraction. Also there was significant correlation between RDW and systolic function (s wave oftissue Doppler) with p value (p value=0.01). Also we found significant correlation between RDW and other parameters age, hypertension, history of ischaemic heart disease. Performing ROC curve analysis between RDW and echocardiography ejection fraction 50% we found that best cut off point to be 16.1 with sensitivity (79.2%) and specificity (62.5%). Conclusion: Finally our study had lent role of RDW prognostication in acute coronary syndrome patients and opened the door for later investigation exploring the specific behavior of RDW in different patient categories.  }, keywords = {Red cell distribution width,Acute Coronary Syndrome,Tissue Doppler}, url = {https://fumj.journals.ekb.eg/article_31293.html}, eprint = {https://fumj.journals.ekb.eg/article_31293_adb655ae292bd1ba8a5c4731d46a6382.pdf} } @article { author = {Kamal, Mahmoud and Hatata, Ragaii and Sadek, Shereen and Salah, Sherif}, title = {Optical Coherence Tomography based criteria for evaluation of Choriodal Neovascularization}, journal = {Fayoum University Medical Journal}, volume = {1}, number = {2}, pages = {36-41}, year = {2018}, publisher = {Fayoum University, Faculty of Medicine}, issn = {2536-9474}, eissn = {2536-9482}, doi = {10.21608/fumj.2018.31294}, abstract = {Purpose: To detect the role of optical coherence tomography in evaluation of Choriodal neovascularization in response to treatment with anti vascular endothelial growth factors (VEGF). Methods: A total of 30 eyes with treatment-naïvechoriodal neovascular membrane were examined using the OCT system before treatment and after treatment with antiVEGF. Results: In treatment‐naïve CNV, The activity of CNV had been evaluated according to structural OCT by presence of Cystoid Macular Edema (CME), Subretinal Fluid (SRF) , Fibrovascular Pigment Epithelial Detachment (FPED) and macular thickening . There is gradual decrease in CMT along the treatment course with repeated intravitreal anti-VEGFinjections. 50 % of CNV patients had CME at baseline which gradually decreased with repeated anti-VEFG injections and disappeared completely after the third dose, 35 % of CNV patients had SRF at baseline which gradually decreased with repeated antiVEFG injections and disappeared completely after the third dose, Only two patients had PED before treatment, which gradually decreased along the course of treatment by three doses of anti VEGF injections. Conclusion:OCT is an important modality of investigation for diagnosis of CNV and detecting activity and response with treatment with anti VEGF.  }, keywords = {Optical Coherence Tomography,choriodal neovascularization,anti VEGF,Cystiod macular edema,subretinal fluid,pigment epithelial detachment}, url = {https://fumj.journals.ekb.eg/article_31294.html}, eprint = {https://fumj.journals.ekb.eg/article_31294_14985610e506c066389634202e743a36.pdf} } @article { author = {El-Tahlawy, Samar and Mohamed, Noha and El-Sayed, Hanaa and Abd-ElRaheem, Talal and Hammad, Mostafa}, title = {Relation of serum vitamin B12 level to premature ejaculation}, journal = {Fayoum University Medical Journal}, volume = {1}, number = {2}, pages = {42-46}, year = {2018}, publisher = {Fayoum University, Faculty of Medicine}, issn = {2536-9474}, eissn = {2536-9482}, doi = {10.21608/fumj.2018.31295}, abstract = {Premature ejaculation (PE) is defined as short ejaculatory latency and lack of control upon ejaculation. Vitamin B12 isan essential and vitally important in DNA synthesis, nervous system functions and regulation of numerous other B12- dependent metabolic processes. vitamin B12 plays integral roles in the metabolism of NO, homo cysteine and 5-HT. The aim of our study was to investigate whether a relationship exists between serum vitamin B12 levels and presence of PE. It was a cross-section, case-control study included 60 subjects divided into 2 groups. Patients group included 30 PE patients, and control group included 30 healthy matched subjects. The participants completed questionnaires concerning sexual health status including Premature Ejaculation Diagnostic Tool (PEDT) and International Index of Erectile Function(IIEF). Serum vitamin B12 was analyzed using ELISA technique. The mean IELT values in the PE group were significantly lower than in the control group (p < .0001). PE patients reported significantly lower vitamin B12 levels compared with the controls (p < .001). Patients with PE had lower vitamin B12 levels compared with normal men with a negative significant correlation between serum vitamin B12 level and PEDT score.  }, keywords = {PE,Vitamin B12,PEDT,IIED}, url = {https://fumj.journals.ekb.eg/article_31295.html}, eprint = {https://fumj.journals.ekb.eg/article_31295_2f706460f76f75ac25d5e85def2de587.pdf} }