@article { author = {Mashahit, Mohamed and Abo El-seoud, Sally and Sayed, Norhan and Abd El-Ghafar, Noha}, title = {Safety and efficacy of the available oral anti diabetic drugs in treating type-2 diabetics during Ramadan1437(Hijri)fasting in Fayoum Governate}, journal = {Fayoum University Medical Journal}, volume = {1}, number = {1}, pages = {49-67}, year = {2018}, publisher = {Fayoum University, Faculty of Medicine}, issn = {2536-9474}, eissn = {2536-9482}, doi = {10.21608/fumj.2018.5429}, abstract = {Introduction : Fasting in Ramadan is one of the five pillars of Islam. Without relevant medical advice and intervention, fasting can put patients with T2DM at an increased risk of serious complications. The aim of this study was to compare the effectiveness and safety of available oral anti diabetic drugs in treating type-2 diabetics during Ramadan fasting.Methods : In this 16-week prospective study, data were collected up to 6 weeks before and after Ramadan fasting . Patients who had received metformin alone or with sulfonylurea (SU), DPP4-I or TZDs or any combination of the before were enrolled into the study.Results : This study concluded that mean total HbA1c improved during Ramadan (𝑃<0.001 ) . This study also found that patients treated with SUs experienced major hypoglycemic events Similarly, a fewer patients experienced weight gain when treated with TZDs. On the contrary we found that there was no evidence of hyperglycemia or hypoglycemia inpatients using DPP4-I.Conclusions: There are several potential benefits of fasting during Ramadan. Active glucose monitoring throughout the holy month of Ramadan enabled us to pick up more hypoglycaemic episodes .The study revealed that the preferred antidiabetic drugs during Ramadan are DPP4-I.}, keywords = {DPP4 inhibitors,Hypoglycemia,sulphonylureas,Type 2 diabetes mellitus,TZDs,Metformin}, url = {https://fumj.journals.ekb.eg/article_5429.html}, eprint = {https://fumj.journals.ekb.eg/article_5429_37f4a05e6e095687a4923900a6be4bfe.pdf} } @article { author = {Mostafa, Randa and shafie, ayman}, title = {The dilemma of humanities in Medical Education}, journal = {Fayoum University Medical Journal}, volume = {1}, number = {1}, pages = {1-4}, year = {2018}, publisher = {Fayoum University, Faculty of Medicine}, issn = {2536-9474}, eissn = {2536-9482}, doi = {10.21608/fumj.2018.5491}, abstract = {}, keywords = {}, url = {https://fumj.journals.ekb.eg/article_5491.html}, eprint = {https://fumj.journals.ekb.eg/article_5491_b54e46f081bb6b10d30bf780ae53f67f.pdf} } @article { author = {Elshafie, Shaira}, title = {Reform Strategies of Medical Education in Egypt}, journal = {Fayoum University Medical Journal}, volume = {1}, number = {1}, pages = {24-27}, year = {2018}, publisher = {Fayoum University, Faculty of Medicine}, issn = {2536-9474}, eissn = {2536-9482}, doi = {10.21608/fumj.2018.5495}, abstract = {– The purpose of this paper is to explore the challenges facing medical education system in Egypt particularly in the area of education quality. It builds upon several existing studies conducted in Egypt to make the case for improving education outcomes. Design/methodology/approach – Samples were drawn from existing studies conducted in Egypt by experts in the education field. Findings– Results suggest that there is a chance for improvement of the quality of medical education in Egypt with subsequent potential increase of graduates employability and direct impact on national and global healthcare.Conclusion–  Strategies of reform are suggested.}, keywords = {Medical education,reform,internalization}, url = {https://fumj.journals.ekb.eg/article_5495.html}, eprint = {https://fumj.journals.ekb.eg/article_5495_c21c6f14f5238df979aeb52ccc33bc8a.pdf} } @article { author = {Bassyouni, Rasha and Gaber, Sylvana and Gomaa, Ahmed and Ali, EL Shaimaa}, title = {Gas6 /TAM system: physiological insights and diseases}, journal = {Fayoum University Medical Journal}, volume = {1}, number = {1}, pages = {5-23}, year = {2018}, publisher = {Fayoum University, Faculty of Medicine}, issn = {2536-9474}, eissn = {2536-9482}, doi = {10.21608/fumj.2018.5502}, abstract = {Growth arrest specific 6 (Gas6) is a multimodular circulating protein, the actions are mediated by the interaction with three transmembrane tyrosine kinase receptors: Tyro3, Axl, and MerTK, named TAM. Their regulatory roles are prominent in the mature immune, reproductive, hematopoietic, vascular, and nervous systems. Gas6 /TAM system plays a role in the regulation of inflammation, coagulation, cell growth, and clearance of apoptotic bodies. Deficiencies in TAM signaling are thought to contribute to chronic inflammatory and autoimmune disease in humans, and aberrantly elevated TAM signaling is strongly associated with cancer progression, and metastasis. We review the function of the Gas6/TAM system and the current evidence supporting its potential role in the pathogenesis of different diseases.}, keywords = {Growth arrest specific 6,tyrosine kinase receptors,TAM}, url = {https://fumj.journals.ekb.eg/article_5502.html}, eprint = {https://fumj.journals.ekb.eg/article_5502_a74e2b08e7032c35571ca7624d29f2e7.pdf} } @article { author = {EL Ashiry, Azza and Gadallah, Mohsen and mashahit, mohamed and Bayoumy, Essam and El-Shafie, shahira and Boulos, Dina}, title = {Vitamin D status Association with newly diagnosed Type2 Diabetes Mellitus: A Case Control Study}, journal = {Fayoum University Medical Journal}, volume = {1}, number = {1}, pages = {40-48}, year = {2018}, publisher = {Fayoum University, Faculty of Medicine}, issn = {2536-9474}, eissn = {2536-9482}, doi = {10.21608/fumj.2018.5505}, abstract = {Diabetes mellitus is one of the most common metabolic diseases in the world that can affect nearly every organ system in the body. Vitamin D has sparked widespread interest in the pathogenesis and prevention of diabetes. The aim of study; to investigate vitamin D level in type 2 diabetes and controls. A retrospective case control study with 47 newly diagnosed diabetic patients aged (35-70 years) and 54 controls matching age±5years and gender. Measuring HbA1c, FBG, assay serum 25(OH) D level  were done for  patients and/or controls. Results of current study, showed a more severe vitamin D deficiency in newly diagnosed diabetes than controls (46.8% vs.33.3%) and difference between vitamin D level in newly diagnosed diabetes compare to controls was  not statistical significant (p=0.108). Conclusion: no statistical significant difference between newly diagnosed diabetes and controls concerning to vitamin D level.}, keywords = {Diabetes mellitus. Type 2 Diabetes mellitus,Vitamin D,vitamin D deficiency}, url = {https://fumj.journals.ekb.eg/article_5505.html}, eprint = {https://fumj.journals.ekb.eg/article_5505_4f8c5aa748499859f52da05665442125.pdf} } @article { author = {Mashahit, Mohamed and Hammad, Ahmed and Shafie, Shaira and Abdelsamad, Basma}, title = {Hypomagnesemia As A Marker Of Diabetic Nephropathy}, journal = {Fayoum University Medical Journal}, volume = {1}, number = {1}, pages = {28-39}, year = {2018}, publisher = {Fayoum University, Faculty of Medicine}, issn = {2536-9474}, eissn = {2536-9482}, doi = {10.21608/fumj.2018.5506}, abstract = {Magnesium is an essential element and has a fundamental role in carbohydrate metabolism in general and in the insulin action in particular. Magnesium is involved in multiple levels in insulin secretion, binding and activity. Cellular magnesium deficiency can alter the activity of the membrane bound Na+K+ ATPase, which is involved in the maintenance of gradients of sodium and potassium and in glucose transport(1).Magnesium depletion has a negative impact on glucose homeostasis and insulin sensitivity in patients with type 2 diabetes as well as on the evolution of complications such as retinopathy, arterial atherosclerosis and nephropathy. Moreover, low serum magnesium is a strong, independent predictor of development of type 2 diabetes(2).A cross sectional study included 105 type 2 diabetic patients. Twenty nine were males (27.6%) and seventy six were females (72.4%).Their ages ranged from 30-77 with a mean of 49.7± 10.6. All patients were subjected to full clinical examination, and investigations which included: serum creatinine, HbA1c, albumin creatinine ratio and serum magnesium.Their mean BMI was 23 kg/m2 and mean waist/hip ratio was 0.9.Their mean HbA1c was 8.55 %. Of all patients, 13 of them had normal level of A/C ratio (control group) and 92 were albuminuric with a mean A/C ratio 238.26 ± 727.9 with a range of 33.7 (0.09-4700), mean s.creatinine was 1.29 ± 1.16 and their mean s.magnesium level was 2.04 ± 0.49 with a range of 1.9 (0.8-3.9).We observed significant negative correlation between A/C ratio and serum creatinine with a p-value of <0.0001.The study shows negative correlation between serum magnesium and A/C ratio(r=-0.202, p=0.039). }, keywords = {Type 2 Diabetes,diabetic nephropathy,albuminura,hypomagnesemia}, url = {https://fumj.journals.ekb.eg/article_5506.html}, eprint = {https://fumj.journals.ekb.eg/article_5506_f4ad7a6ea954e706c47f0b44ae62a621.pdf} }